SQUAMOUS CELL CARCINOMA IN PROLIFERATIVE VERRUCOUS LEUKOPLAKIA: A CASE REPORT

Abstract

Proliferative verrucous leukoplakia (PVL) is a multifocal and progressive lesion with a high rate of transformation into squamous cell carcinoma (SCC). A 57-year-old white female patient sought help regarding 2 oral lesions. She denied a history of smoking or alcohol use. During examination, an exophytic lesion was noted on the left inferior alveolar ridge. The lesion had a verrucous surface, was sessile, white, rough, with defined edges and 2 cm in size. On the right superior anterior alveolar ridge, a white lesion was found with plain characteristics, was noted to be painless and with defined edges 3 cm in size. Diagnostic hypotheses were SCC, verrucous carcinoma, and PVL. Two incisional biopsies were performed on different areas. The histopathologic examination confirmed SCC on the inferior area and leukoplakia with moderate epithelial dysplasia on the superior area. The leukoplakia was removed and the patient was forwarded to a head and neck surgeon to treat the SCC and these patients are under continued monitoring. Proliferative verrucous leukoplakia (PVL) is a multifocal and progressive lesion with a high rate of transformation into squamous cell carcinoma (SCC). A 57-year-old white female patient sought help regarding 2 oral lesions. She denied a history of smoking or alcohol use. During examination, an exophytic lesion was noted on the left inferior alveolar ridge. The lesion had a verrucous surface, was sessile, white, rough, with defined edges and 2 cm in size. On the right superior anterior alveolar ridge, a white lesion was found with plain characteristics, was noted to be painless and with defined edges 3 cm in size. Diagnostic hypotheses were SCC, verrucous carcinoma, and PVL. Two incisional biopsies were performed on different areas. The histopathologic examination confirmed SCC on the inferior area and leukoplakia with moderate epithelial dysplasia on the superior area. The leukoplakia was removed and the patient was forwarded to a head and neck surgeon to treat the SCC and these patients are under continued monitoring.