Abstract
Described in 1985 by Hansen et al., proliferative verrucous leukoplakia (PVL) is a rare sub-type of leukoplakia characterized by the high rate of cancerization (above 70%). Here, we describe a 62-year-old female patient, non-smoker and non-drinker, who in 2016 had white striated plaques on bilateral jugal mucosa, lower border, and border of tongue. Initially it was interpreted as oral lichen planus and was histologically compatible with the clinical diagnosis. In 2018, the lesions spread through the oral mucosa (oral floor, border of tongue, alveolar ridge, lower gingiva, and soft palate), with verrucous and pigmentation areas. Three new biopsies were performed in different areas and showed hyperkeratosis without dysplasia. Thus, the patient met the criteria of Cerero-Lapiedra for PVL. During the 2019 follow-up, reddish areas were observed in the inferior ridge, and a new biopsy was performed, without diagnosis of oral squamous cell carcinoma. The patient is under close monitoring.
Published Version
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