Abstract
1. Glial cell proliferation has been studied with radioautographic technique using tritium-labelled thymidine in the hypoglossal nucleus of rabbits during the first six days after nerve crush. 2. Glial cells on the unoperated side show a slight, insignificant increase in number of labelled glial cells compared to control animals. In control hypoglossal nucleus, around one cell per 1000 glial cells is labelled. 3. During the 2nd to 4th day after nerve crush the glial cells in the regenerating nucleus show a tenfold increase in number of labelled glial cells compared to the unoperated side. This increase in glial cell labelling coincides with the outgrowth of new axons and the initial period of neuronal changes. 4. The dominating number of labelled nuclei are of microglial type with a tendency to pericapillary location. 5. Concomitant with the increased glial cell labelling, mitotic figures are seen in glial cells surrounding the regenerating neurons. The quotient glial labelling index: mitotic index is comparable to the same value in other proliferative processes outside the brain. 6. Increased numbers of labelled cells are seen in the capillary walls of the regenerating nucleus at the same time as the increased glial cell labelling.
Published Version
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