Proliferation PET/CT Imaging of Salivary Gland Tumor.

Ryogo Minamimoto

doi:10.3390/diagnostics11112065

Ryogo Minamimoto

Open Access

https://doi.org/10.3390/diagnostics11112065

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Journal: Diagnostics	Publication Date: Nov 8, 2021
Citations: 2	License type: CC BY 4.0

Affiliation: National Center for Global Health and Medicine

Abstract

Salivary gland tumors are rare neoplasms which vary in terms of origin and malignant potential. 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET) has limited ability to differentiate between different types of salivary gland tumors because both Warthin’s tumors and pleomorphic adenomas usually show increased FDG uptake, with no statistically significant difference in standardized uptake value (SUV) compared with malignant salivary gland tumors. Here, we discuss 4′-[methyl-11C]-thiothymidine (4DST) PET, which provides cell proliferation imaging capable of demonstrating intense uptake in parotid carcinoma and Warthin’s tumor, but no uptake in parotid pleomorphic adenoma. This is the first report of the potential of proliferation PET/ computed tomography (CT) imaging for characterizing salivary gland tumors based on the molecular pathogenesis of the tumor.

Highlights

Salivary gland tumors are rare neoplasms which vary in terms of origin and malignant potential. 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET) has limited ability to differentiate between different types of salivary gland tumors because both Warthin’s tumors and pleomorphic adenomas usually show increased FDG uptake, with no statistically significant difference in standardized uptake value (SUV) compared with malignant salivary gland tumors
The potential of 4DST PET/computed tomography (CT) for characterizing head and neck squamous cell carcinoma has been reported, with uptake values lower than those for FDG, which shows a similar tendency to the present case [4]
The basal cells of the epithelium and the abundant lymphoid tissue of Warthin’s tumors are possibly related to uptake in proliferation PET; given their slow-growing nature, 4DST uptake might be affected by reactive lymphoid tissue rather than the epithelium

Summary

Introduction

Salivary gland tumors are rare neoplasms which vary in terms of origin and malignant potential. 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET) has limited ability to differentiate between different types of salivary gland tumors because both Warthin’s tumors and pleomorphic adenomas usually show increased FDG uptake, with no statistically significant difference in standardized uptake value (SUV) compared with malignant salivary gland tumors. Proliferation PET/CT Imaging of Salivary Gland Tumor. Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Results

Conclusion