Abstract
Here, we fabricated composite scaffolds consisting of poly ε-caprolactone (PCL) and silanated silica particles and evaluated the performance of these composite scaffolds as suitable alternatives for bone tissue regeneration including their physical properties (tensile modulus, wettability, and surface roughness) and biological properties (cell proliferation, osteogenic differentiation, Q-PCR, western blotting, and migration assay), by culturing human mesenchymal stem cells. PCL/silanated silica scaffolds had outstanding physical characteristics and biological properties including cell proliferation, osteogenic differentiation, and osteoinduction. This silanated-silica composite has a strong potential as a biomaterial and can be applied to bone tissue applications.
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