Abstract
PROSTAGLANDIN (PGF2α) induces lactogenesis and advanced parturition when injected into pregnant rats1. A luteolytic effect of PGF2α has also been demonstrated in pseudopregnant and pregnant rats3,4, normal guinea-pig5, autotransplanted sheep ovary6 and pregnant hamster7. The decrease of plasma progesterone concentration before parturition8–10 will trigger the release of prolactin and other hormones from the hypophysis and induce lactogenesis11–13 which in the normal pregnant rat occurs around 12 h before parturition13.
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