Abstract
Synthetic pyroglutamyl-histidyl-prolinamide or thyrotropin-releasing-hormone (TRH) stimulates secretion of prolactin (PRL) as well as thyrotropin (TSH) but has no consistent effect on serum levels of growth hormone (GH), luteinizing hormone (LH) or follicle stimulating hormone (FSH) in man. After intravenous injection of as little as 10 μg TRH, both serum PRL and TSH levels rise rapidly. The PRL and TSH response was greater in normal women than in normal men and both responses were greatly enhanced in hypothyroid patients and virtually abolished in hyperthyroid patients. The possibility that p-Glu-His-Pro-NH 2 is also a “natural physiological” regulator of PRL in man is evident.
Published Version
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