Abstract
The main factor to maintain or growth of prostate is a testosterone. It is widelyaccepted that testosterone is necessary to be converted to dihydrotestosterone (DHT) to express its effect on the prostate. The 5α-reductase activity is reportedly under the control of the prolactin (PRL) and enhanced by testosterone and PRL, though PRL in the regulation of prostate growth is still controversial. The mastomys [Praomys (mastomys) natalensis] is an experimental animal unique for the female as well as the male having the morphologically functional prostate with two efferent ducts. In the present study, hormonal influence on the growth and maintenance of the prostate gland was studied in the mastomys of both sexes.Gonadectomized animals were grafted with the pituitary gland or further treated with testosterone or bromocriptine. The prostate weight decreased by castration and the administration of testosterone alone increased the prostate weight in both sexes. Furthermore, the decrease in the organ weights in both sexes due to castration was restored by pituitary graft, and the restoring response was higher in females than in males. Proliferation of epithelial cells was induced by administration of testosterone or grafting the anterior pituitary.
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