Progression of visual field in patients with primary open‐angle glaucoma (2): Level of progression

Abstract

AbstractPurpose To compare the visual field rate (VF) of progression of non evolutive and evolutive patients with treated ocular hypertension (OHT) or primary‐open angle glaucoma (POAG).Methods From a multicentric database, 441 eyes of 228 patients with treated OHT or POAG followed up at least 6 years with Humphrey 24.2 Sita‐Standard VF exam at least twice a year were identified and classified in 5 groups: 104 OHT, 205 early glaucoma (MD>‐6dB), 45 moderate glaucoma (MD‐6 to ‐12dB), 41 advanced glaucoma (MD‐12 to ‐18dB) and 46 severe glaucoma (MD<‐18dB). With final datas, patients were classified in 2 sub groups: “evolutive” or “stable” patients if worsening or not to upper grade. Rate of progression during follow‐up period was calculated using the trend analysis of the Guided Progression Analysis software.Results The mean follow‐up was 8.4 years. We found respectively for “stable” and “evolutive” sub‐groups, following rates of progression : MD =‐0.01 and ‐0.13dB/year (‐0.03& ‐0.41%VFI/year) in eyes with OHT, ‐0.07& ‐0.80dB/year (‐0.23 & ‐2.39%VFI/year) in early glaucoma group, ‐0.02& ‐0,91 dB/year (‐0.46 & ‐3.04%VFI/year) in moderate glaucoma, ‐0.21 & ‐0.82dB/year (‐1.13 & ‐3.57%VFI/year) in advanced glaucoma.Conclusion In early to advanced stages of glaucoma, “stable” patients showed a low rate of progression, compared to “evolutive” subgroup with a common rate around ‐0.80dB/year. These values could represent a landmark of evolution in glaucoma.