Abstract
Variants in FAM13A(family with sequence similarity 13 member A) have been found in genome-wide association studies(GWAS) to associate with lung function in several common chronic lung diseases(CLD) such as asthma, chronic obstructive pulmonary disease(COPD), as well as in idiopathic interstitial pneumonias(IIP). This gene was cloned in 2004, yet the function of encoded protein is unknown.Its genetic contribution in CLD suggests a major function of this gene both in lung physiology and CLD.This review provides a brief summary of the current research of FAM13A, and demonstrates the necessity to study its biological function besides its well accepted genetic contribution.Further interpretations of FAM13A variants may help in understanding of CLD mechanisms and offer opportunity for intervention. Key words: FAM13A gene; Asthma; Chronic obstructive pulmonary disease
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