Abstract
Gene therapy is a technique that uses genes to treat or prevent diseases. Gene therapy to the brain faces other difficulties in addition to the general issues one faces with gene therapy. A major limiting factor for the delivery of gene to the brain is the blood brain barrier (BBB), which most gene expression vectors can not cross naturally. However, recent advances in gene transfer technology have led to promises for delivery of therapeutic genes to brain. In this small review we shall make a discussion on the recent developments of gene therapies for some important neurodegenerative disorders.
Highlights
Progresses in Gene Therapy of Neurodegenerative DisordersAshim Kumar Basak and Tridip Chatterjee* Department of Molecular Biology, Institute of Genetic Engineering, India Received: January 25, 2018; Published: February 15, 2018 *Corresponding author: Tridip Chatterjee, Department of Molecular Biology, Institute of Genetic Engineering, India
Gene therapy is the administration of genetic materials into the somatic cells of a patient that exert therapeutic effects by correcting genetic defects, over expression of desired proteins or inhibition of the expression of unwanted harmful proteins [1]
Recent advances in gene transfer technologies show promise for delivery of therapeutic genes to brain for the replacement of defective proteins, neuroprotection, restoration of neuronal functions etc [2]
Summary
Ashim Kumar Basak and Tridip Chatterjee* Department of Molecular Biology, Institute of Genetic Engineering, India Received: January 25, 2018; Published: February 15, 2018 *Corresponding author: Tridip Chatterjee, Department of Molecular Biology, Institute of Genetic Engineering, India
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