Abstract
Inflammation, immune suppression and oxidative stress is the main pathogenesis of sepsis.In recent years, more study have found ω-3 polyunsaturated fatty acid(ω-3PUFA) can inhibit inflammation by some mechanisms namely, reducing metabolites from arachidonic acid(AA)by competing with it through a variety of ways, alteration of membrane lipid rafts, inhibition of nuclear receptor activation(specifically nuclear factor NF-κB)to modulate production of inflammatory mediators, and metabolism into novel pro-resolving and anti-inflammatory mediators(resolvins and protectins). In addition, ω-3PUFA can reduce oxidative stress by improvement the antioxidant defense system, etc.Many clinical studies have demonstrated that ω-3PUF is effective in the for sepsis patients.The paper reviews the specific mechanism of ω-3PUFA treatment for sepsis. Key words: Sepsis; Immune nutrition; Fish oil fat emulsion; Omega-3 polyunsaturated fatty acid; Inflammation; Oxidative stress
Published Version
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