Abstract
Circular RNAs (Circ RNAs) are a group of endogenous non-coding RNAs (ncRNAs) which widespread in eukaryotic cells, and have been brought to the research hotspots recently. As a member of ncRNAs, Circ RNAs may play an important part in diseases by regulating target gene expressions, via epigenetic modifications. Colorectal Cancer (CRC) is a common malignant tumor worldwide, and its progress may be attributed to the dysfunctional expressions of target genes. Recent studies indicate that abnormal levels of Circ RNAs are detected in CRC cells, which may have a potential impact on this cancer. This review focus on the current understandings of the roles of Circ RNAs in CRC, with an aim to provide new aspects to the clinical diagnosis and therapy of CRC.
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