Abstract

The Rab Family contains over 60 genes in the human genome and contributes to regulation of transporting vesicles.It has become increasingly clear that altered expression levels and mutations of Rab would lead to disruption of transporting vesicles,the cargo could not and then be transported in target compartments.Finally,It might be associated with physiological disorder and diseases such as genetic disorders,Alzheimer' s disease and cancer.We discusses the relationship between deviant of Rab and genetic disorders in this review. Key words: Rab protein; Transport vesicles; Genetic disorders

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