Progress in Pathogenesis of Pancreatitis with Acute Kidney Injury

Abstract

Acute pancreatitis (AP) is a common gastrointestinal disease. About 20% of patients with acute pancreatitis develop severe acute pancreatitis, often with multiple organ dysfunction and poor prognosis. In the process, about 10% of patients develop acute renal injury (AKI). Acute renal injury (AKI) is a major complication of severe pancreatitis with a case fatality rate of up to 75%. AP associated AKI (AP-AKI) has both common and significant differences from other AKIs associated with intensive care. Although its pathogenesis is not clear, systemic and regional inflammatory responses play a key role. Early detection, early and effective support and pathogen treatment can significantly improve the results.