Abstract
Dearomatization reactions are among the most straightforward and efficient methods for creating sp3-rich cyclic systems from simple, readily available arenes. These reactions have been widely applied in the total synthesis of natural products, medicinal chemistry, and material sciences. The fruitful development of dearomatization strategies and methodologies targeting single aromatic substrate over the past decades has paved the way for more sophisticated multiple dearomatization processes, which offer greater advantages in constructing molecular complexity. Double dearomatization reactions have made significant pioneering strides in recent years. This review will provide an overview of the strategies and detailed examples of multiple dearomatization reactions involving various aromatic compounds, along with a discussion of the related mechanisms and the major challenges that remain in this intriguing yet formidable field.
Published Version
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