Abstract
Human cytomegalovirus(HCMV) is a ubiquitous herpesvirus.It is always a serious pathogen in immunosuppressed individuals,and also the most common and harmful agent causing congenital infection and birth defects.Biological functions of the encoded proteins in HCMV UL/b' region,which is deleted in the HCMV laboratory AD169 strain,have been explored in depth in recent years,and the results demonstrate that the proteins have important roles in HCMV virulence,transmission,tropisms and immune escape and so on.UL133-UL138 locus can promote to establish and maintain HCMV latent infections,and pUL1 38 is the first HCMV protein demonstrated to promote infection with the hallmarks of latency in CD34 + hematopoietic progenitor cells (HPC).Therefore,the products expressed by the gene of HCMV UL/b' region are crucial in the course of HCMV infection.This article reviews the genetic structure and biological functions of encoded proteins in HCMV UL/b' region,especially pULl38 which is related with HCMV latent infections.It will be greatly significant to clarify the pathogenesis of HCMV infection. Key words: Human cytomegalovirus; UL/b' region; UL138 gene; Latent infection; Biological function
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
