Abstract
Progress and Challenges in the Understanding of Chronic Urticaria
Highlights
Chronic urticaria is a skin disorder characterized by transient pruritic weals that recur from day to day for 6 weeks or more
We examined the response of basophils of healthy donors, atopic donors, and patients with chronic urticaria to a variety of stimuli, including anti-IgE, bradykinin,[33] monocyte chemotactic protein (MCP)-1,34 C5a,9,10,35 and serum
The basophils of chronic urticaria patients seem to be less responsive to stimuli, such as anti-IgE or C5a, which act through different receptors, the abnormality does not seem to be due to a general impairment of signaling since chronic urticaria basophils respond normally to other stimuli that act independently from the IgE receptor, such as A23187, formyl-met-leu-phe (FMLP), and platelet-activating factor,[41] in addition to bradykinin[33] and MCP-1.42
Summary
Chronic urticaria is a skin disorder characterized by transient pruritic weals that recur from day to day for 6 weeks or more. When we stimulated mast cells, histamine, leukotrienes, and IL-4 were produced, and activation of mast cells by chronic urticaria sera was closely correlated with the ability to activate basophils.[21] These observations agree with the study reported by Yasnowsky and colleagues, who found CD203c expression on incubation of basophils with chronic urticaria sera. We did not find significant differences when comparing the ratio of IFN-c to IL-4 production by CD4+ or CD8+ lymphocytes of control subjects and urticaria patients.[21] These data strengthen previous studies suggesting an immune basis for chronic urticaria since we demonstrate that the CD4+ lymphocytes of patients with this disease are activated (or primed) and release greater amounts of cytokines employing a nonspecific stimulus. The cellular infiltrate associated with chronic urticaria was interpreted to represent either a Th0 profile[27] or a mixture of activated Th1 and Th2 cells
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