Abstract
Objective: The aim of this study was to evaluate the prognostic value of VEGF and IL-8 in pleural effusion in patients with lung cancer.Materials and method: Commercially available ELISA was used to determine VEGF and IL-8 levels.Results: The level of VEGF showed significant correlations with lymph node metastasis and distant metastasis. But, IL-8 was only correlated with lymph node metastasis. Univariate and multivariate analysis revealed elevated VEGF level was an independent predictor of shorter OS and DFS.Conclusion: VEGF could be an important component that contributes to pleural effusion formation, and an important prognostic factor for lung cancer.
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