Abstract
Aquaporins (AQPs), a family of transmembrane channel, are composed of 13 identified members (AQP0–12). Accumulating evidences reported that AQPs were correlated with various biological roles and represented a prognostic predictor in various cancer types. However, the prognostic value of AQPs expression in ovarian cancer remains unclear. Using ‘Kaplan–Meier plotter’ (KM plotter) online database, we explored the predictive prognostic value of individual AQPs members’ mRNA expression to overall survival (OS) in different clinical data, such as histology, pathological grades, clinical stages, TP53 status, and applied chemotherapy in ovarian cancer patients. Our results revealed that higher AQP0, AQP1, and AQP4 mRNA expression were correlated with poor OS, whereas higher AQP3, AQP5, AQP6, AQP8, AQP10, and AQP11 showed better OS in ovarian cancer patients. Moreover, AQP4 and AQP8 showed poor OS in TP53-mutated ovarian cancer patients and AQP1 presented unfavorable OS in both TP53 mutated and wild ovarian cancer patients. Additionally, AQP3, AQP6, and AQP11 mRNA expression were correlated with better OS, whereas AQP0 and AQP1 showed poor OS in all ovarian cancer patients treated with Platin, Taxol, and Taxol + Platin chemotherapy. AQP5, AQP8, and AQP10 were associated with improved OS, however, AQP4 predicted unfavorable OS in all patients treated with Platin chemotherapy. Our results suggest that individual AQPs, except AQP2 and AQP9, are associated with unique prognostic significance and may thus act as new predictive prognostic indicators and potential drug therapeutic target in ovarian cancer.
Highlights
Ovarian cancer contributes to most of the deaths from all gynecologic malignancies
Amongst the members of AQPs family, only AQP2 and AQP9 mRNA had no effect on the overall survival (OS) of ovarian cancers, i.e. AQP0, AQP1, and AQP4 mRNA expression were associated with poor OS, whereas high expression of AQP3, AQP5, AQP6, AQP8, AQP10, and AQP11 were associated with better OS for ovarian cancer patients
We found that high level of AQP1, AQP4, and AQP8 mRNA expression in TP53 mutation and AQP1 mRNA expression in TP53 wild-type ovarian cancer patients were correlated with poor survival rate, indicating that mutation of TP53 gene might regulate AQP1, AQP4, and AQP8 expression and participation in the development of ovarian caners
Summary
Ovarian cancer contributes to most of the deaths from all gynecologic malignancies. It is the fifth leading cause of female health problems and deaths all over the world due to cancer [1]. Ovarian cancer patients are diagnosed at an advanced stage; in recent years combined treatment of debulking surgery and chemotherapy have yielded a modest improvement in survival as a standard therapy [2]. Considerable advances are present in early detection, chemotherapy, radical cure surgery, and targetted therapeutic management, many cases still (approximately 85%) recur [4] and develop gradual treatment resistance with lower 5-year survival rate (30%) [5]. Early establishment of a novel prognostic marker in ovarian cancer is the urgent requirement for the better prognosis and to improve clinical outcomes of these patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
