Prognostic value of left ventricular trabeculae fractal analysis in patients with dilated cardiomyopathy

Abstract

The prognostic value of left ventricular (LV) myocardial trabecular complexity on cardiac magnetic resonance (CMR) in dilated cardiomyopathy (DCM) remains unknown. This study aimed to evaluate the prognostic value of LV myocardial trabecular complexity using fractal analysis in patients with DCM. Consecutive patients with DCM who underwent CMR between March 2017 and November 2021 at two hospitals were prospectively enrolled. The primary endpoints were defined as the combination of all-cause death and heart failure hospitalization. The events of cardiac death alone were defined as the secondary endpoints.LV trabeculae complexity was quantified by measuring the fractal dimension (FD) of the endocardial border based on fractal geometry on CMR. Cox proportional hazards regression and Kaplan-Meier survival analysis were used to examine the association between variables and outcomes. The incremental prognostic value of FD was assessed in nested models. A total of 403 patients with DCM (49.31±14.68 years, 69% male) were recruited. After a median follow-up of 43 months (interquartile range, 28-55 months), 87 and 24 patients reached the primary and secondary endpoints, respectively. Age, heart rate, New York Heart Association (NYHA) functional class >II, N-terminal pro-B-type natriuretic peptide (NT-proBNP), LV ejection fraction (LVEF), left ventricular end-diastolic volume index (LVEDVi), left ventricular end-systolic volume index (LVESVi), LV mass index (LVmassi), presence of late gadolinium enhancement (LGE), global FD, LV mean apical FD, and LV maximal apical FD were univariably associated with the outcomes (all P<0.05). After multivariate adjustment, LV maximal apical FD remained a significant independent predictor of outcome [Hazard ratio = 1.179 (CI 1.116, 1.246), P < 0.001]. The addition of LV maximal apical FD in the nested models added incremental prognostic value to other common clinical and imaging risk factors (all <0.001; C-statistic: 0.84 to 0.88, P< 0.001). LV maximal apical FD was an independent predictor of the adverse clinical outcomes in patients with DCM and provided incremental prognostic value over conventional clinical and imaging risk factors.