Abstract
BackgroundAs is well recognized that inflammation plays a crucial role in the genesis and progression of various cancer. Here we investigate the prognostic value of a novel index: the combination of neutrophil to lymphocyte ratio and platelet distribution width (coNLR-PDW) in post-operation patients with resectable hepatocellular carcinoma (HCC).MethodsThe receiver operating characteristic (ROC) curve was utilized to determine the optimal cutoff values of continuous variables, including the neutrophil-lymphocyte ratio (NLR) and platelet distribution width (PDW). Kaplan-Meier method and the Log-rank test were used to compare survival differences across three groups stratified by the coNLR-PDW score. Univariate and multivariate Cox proportional hazard regression analyses were adopted to identify independent factors of HCC patient’s prognosis.Results1.59 and 13.0 were perceived as the optimal cutoff value for NLR and PDW based on the ROC curve, respectively. Kaplan-Meier method revealed that a higher coNLR-PDW score predicts poorer overall survival (OS) and disease-free survival (DFS) (P < 0.001). coNLR-PDW was demonstrated as an independent factor for both OS and DFS using Cox regression analysis in training and validation cohort.ConclusioncoNLR-PDW is recognized as a valuable biomarker for predicting the survival of patients with HCC.
Highlights
As is well recognized that inflammation plays a crucial role in the genesis and progression of various cancer
Elevated platelet counts are significantly associated with poor prognosis in numerous cancers, including vulvar squamous cell cancer, lung cancer, renal cell carcinoma, pancreatic cancer, ovarian cancer, and colorectal cancer [7,8,9,10,11,12,13]
Patient demographics We included a total of 250 hepatocellular carcinoma (HCC) patients who underwent radical hepatectomy at the Third Affiliated Hospital of Sun Yat-sen University, including 225 men and 25 women
Summary
As is well recognized that inflammation plays a crucial role in the genesis and progression of various cancer. We investigate the prognostic value of a novel index: the combination of neutrophil to lymphocyte ratio and platelet distribution width (coNLR-PDW) in post-operation patients with resectable hepatocellular carcinoma (HCC). Researchers have found that systemic inflammatory responses play an essential role in the progression of cancer [2, 3]. Platelets play a crucial role in the progression and metastasis of cancer. Platelet distribution width (PDW), as an essential parameter for activated platelets, plays a vital role in a variety of tumors, including gastric cancer, melanoma, breast cancer, lung cancer, nasopharyngeal cancer, laryngeal cancer [14,15,16,17,18]
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