Abstract
256 Background: Women with pancreatic cancer (PC) are known to have a longer overall survival compared with men. However, no data address the association of gender with acute medical complications in the inpatient setting. We hypothesize that women with PC have fewer inpatient medical complications than men. Methods: The Nationwide Inpatient Sample (NIS) database was queried to identify all non-surgical hospital admissions for patients with a diagnosis of pancreatic cancer for 2011. We compared inpatient complications and mortality between females and males with PC using univariate and multivariate logistic regression model. Two sample independent t-tests were used to compare all linear variables, and Chi-squared tests were used to compare categorical data. Results: Of the 16,616 PC patients analyzed, there were 8,324 females (F) and 8,292 males (M). Mean age was 69 (F) and 67 (M). Length of stay for both averaged 6 days. After adjusting for gender, age, race, inpatient chemotherapy, and comorbidities (depression, alcoholism, arthritis, coagulopathies, drug use, diabetes, hypertension, hypothyroidism, liver disease [dz], metastatic dz, obesity, perivascular dz, renal failure), multivariate analysis showed that male gender in PC patients is independently associated with increased incidence of pneumonia (p<0.001, RR 0.77), pulmonary embolism (p=0.006, RR 0.80), ileus (p=0.001, RR 0.79), and acute renal failure (p<0.001, RR 0.76). Female patients experienced higher incidence of urinary tract infection (p<0.001, RR 1.9). Although incidence of mortality for male patients with PC was higher by univariate analysis (p= 0.005), it was not significantly higher by multivariate analysis (p= 0.087). Conclusions: In this study, men admitted with PC suffer higher incidences of inpatient complications compared to women. These findings may partly explain the higher overall survival rate of women compared to men with PC. It also implicates gender as prognostic tool in the management of hospitalized PC patients.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
