Abstract
BackgroundFactors indicative of a negative prognosis for appendicular osteosarcoma (OSA) in dogs are visible metastatic disease, location, and size of lesion. In human medicine maximum standard uptake value (SUVmax), as measured on a fluorine18 flourodeoxyglucose positron emission tomography/computed tomography (18F‐FDG PET/CT), is prognostic for survival for several tumor types.ObjectiveDetermine if SUVmax is associated with progression‐free interval (PFI) and determination of survival in dogs with appendicular OSA.AnimalsSixty‐two dogs with untreated appendicular OSA that had been staged with 18F‐FDG PET/CT.MethodsRetrospective analysis of the 18F‐FDG PET/CT was performed. Dogs were excluded from the study if they did not receive definitive intent treatment for their primary OSA and adjuvant chemotherapy with carboplatin, or had visible metastatic disease on initial imaging. A region of interest (ROI) was created around the primary tumor to measure SUVmax. Univariable and multivariable Cox proportional hazards analysis was performed to evaluate for associations between variables including SUVmax and outcome of PFI and overall survival (OS).ResultsMaximum standard uptake value of the primary tumor was significantly associated with the OS (P = .04) with adjustment for treatment type and monocyte count. The overall median survival time (OST) was 284 days (range, 39‐1293 days) with the OST of dogs having an SUVmax of ≥7.4 of 254 days (range, 98‐428 days) and dogs with an SUVmax of <7.4 of 680 days (range, 108‐811 days, P = .01).Conclusions and Clinical ImportanceMaximum standard uptake value as measured via 18F‐FDG PET/CT is significantly associated with survival in dogs with appendicular OSA with a high SUVmax being an indicator of a negative prognosis.
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