Abstract
BackgroundThe association between platelet distribution width (PDW) and cancer has been evaluated by a few studies, but the influence of PDW on cancer prognosis is unclear. Therefore, we conducted the present meta-analysis.Material/MethodsWe identified relevant research using identical search strategies. The influence of PDW level on cancer prognosis, as well as clinical characteristics, was analyzed.ResultsA total of 11 studies comprising 2625 cancer patients were included in our meta-analysis. The results suggested that high PDW level was obviously related to poor OS (HR=1.54, 95%CI 1.18–2.00), especially for breast cancer (HR=1.21, 95%CI 1.07–1.36) and pharyngolaryngeal cancer (HR=3.06, 95%CI 1.68–5.57). Furthermore, high PDW was obviously related to poor OS both in older and younger subgroups, with combined HR estimates of 1.58 (95%CI 1.15–2.16) and 1.64 (95%CI 1.19–2.26), respectively. High PDW level was notably related to poor OS in the cut-off value ≥16% subgroup (HR=1.84, 95%CI 1.01–3.40). Moreover, high PDW level was obviously associated with lymph node metastasis (OR=1.43, 95%CI 1.04–1.99).ConclusionsThe findings of this study suggest that PDW is an effective and convenient indicator of cancer prognosis. Furthermore, high PDW level is obviously associated with lymph node metastasis.
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