Abstract
Published evidence on the prognostic significance of lymphocyte‐to‐monocyte ratio (LMR) in diffuse large B‐cell lymphoma (DLBCL) is controversial. We performed an updated meta‐analysis from 12 reports with 5021 patients to more accurately evaluate the prognostic value of LMR in DLBCL. Herein, we confirmed that patients with low LMR had shorter overall survival and progression‐free survival than those with high LMR in DLBCL. Subgroup analyses indicated that patient source, cut‐off values of LMR, treatment methods, and sample size showed similar prognostic performance in DLBCL patients. No significant heterogeneity was observed for progression‐free survival (PFS, P het = 0.192) among the enrolled studies. The meta‐analysis suggests that the LMR may be a potential biomarker in the prediction of clinical outcomes for DLBCL patients.
Highlights
Published evidence on the prognostic significance of lymphocyte-to-monocyte ratio (LMR) in diffuse large B-cell lymphoma (DLBCL) is controversial
Eleven studies explored the association of LMR and overall survival (OS), while seven studies investigated the correlation of LMR and progression-free survival (PFS)
Mounting evidence shows a correlation between LMR and survival of DLBCL patients
Summary
Published evidence on the prognostic significance of lymphocyte-to-monocyte ratio (LMR) in diffuse large B-cell lymphoma (DLBCL) is controversial. The meta-analysis suggests that the LMR may be a potential biomarker in the prediction of clinical outcomes for DLBCL patients. The absolute lymphocyte count (ALC) and absolute monocyte count (AMC), surrogate markers of tumor microenvironment, have been reported as prognostic factors to predict outcomes of DLBCL patients [9]. Recent studies showed that the ALC/AMC (lymphocyte-to-monocyte ratio, LMR) is considered as a prognostic marker of tumor microenvironment in DLBCL patients [10,11]. Abbreviations ALC, absolute lymphocyte count; AMC, absolute monocyte count; CI, confidence interval; CRP, C-reactive protein; DLBCL, diffuse large B-cell lymphoma; HR, hazard ratio; LMR, lymphocyte-to-monocyte ratio; NLR, neutrophil-to-lymphocyte ratio; OS, overall survival; PFS, progression-free survival; PLR, platelet-to-lymphocyte ratio
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