Abstract
BackgroundEpidermal growth factor receptor (EGFR) has been shown to have abnormal expression in many human cancers and is considered as a marker of poor prognosis. Frequency of over expression in bladder cancer has not been studied in our population; therefore we aimed to evaluate the frequency and prognostic significance of EGFR immunohistochemical expression in locoregional population.MethodsWe performed EGFR immunohistochemistry on 126 cases of bladder cancer and association of EGFR expression with tumor grade, lamina propria invasion, deep muscle invasion and recurrence of disease was evaluated.ResultsHigh EGFR expression was noted in 26.2% (33 cases), 15.1% (19 cases) and 58.7% (74 cases) revealed low and no EGFR expression respectively. Significant association of EGFR expression was noted with tumor grade, lamina propria invasion, deep muscle invasion and recurrence status while no significant association was seen with age, gender and overall survival. Kaplan- Meier curves revealed significant association of EGFR expression with recurrence while no significant association was seen with overall survival.ConclusionSignificant association of EGFR overexpression with tumor grade, muscularis propria invasion and recurrence signifies its prognostic value; therefore EGFR can be used as a prognostic biomarker in Urothelial bladder carcinoma.
Highlights
Epidermal growth factor receptor (EGFR) has been shown to have abnormal expression in many human cancers and is considered as a marker of poor prognosis
Frequency of over expression in bladder cancer has not been studied in our population; we aimed to evaluate the frequency and prognostic significance of EGFR immunohistochemical expression in locoregional population
Mean age of patients was 63.61 ± 14.49 years with male to female ratio of 2.6:1. 96% specimens were of transurethral resections. 48.4% (61 cases) were of high grade morphology, Table 2 Association of EGFR Expression with clinicopathologic features of Urothelial carcinoma
Summary
Epidermal growth factor receptor (EGFR) has been shown to have abnormal expression in many human cancers and is considered as a marker of poor prognosis. Most of the bladder tumors have transitional cell (urothelial) morphology and they have a natural propensity to progress from superficial non-invasive tumors to deep muscle invasive cancers [2]. The single most important factor for determining disease prognosis in bladder cancer is muscle invasion; the presence of which makes therapeutic approach more radical. The only therapeutic option for muscle invasive bladder cancer is radical cystectomy or radical radiotherapy; 5 year survival remains poor [3, 4]. Epidermal growth factor receptor (EGFR) has been shown to have abnormal expression in many human cancers and is considered as a marker of poor prognosis [6]. Frequency of over expression in bladder cancer has not been studied in our population; we aimed to evaluate the frequency and prognostic significance of EGFR immunohistochemical expression in locoregional population
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