Prognostic significance of cachexia score assessed by CT in male patients with small cell lung cancer.

Abstract

To determine the prognostic significance of CT-determined cachexia scores (CSs) in 127 consecutive male small cell lung cancer (SCLC) patients, cross-sectional areas of muscle and fat tissues at the third lumbar vertebra (L3) were retrospectively measured on baseline CT images. CSs were determined based on the presence of sarcopenia and/or adipopenia. According to the presence of sarcopenia (L3 muscle index <55cm2 /m2 , 86.8%) and adipopenia (L3 fat index <22cm2 /m2 , 11.8%), CSs were defined as follows: CS2 (sarcopenia and adipopenia, 11.8%), CS1 (sarcopenia only, 74.8%) and CS0 (13.4%). CS2 was significantly related to lower body mass index (p<.001) and poor performance status (p=.002), and patients with CS2 had shorter OS than patients with CS1 or CS0 (median OS, 5.0months vs. 8.9months vs. 18.3months; p=.007). Multivariable analysis revealed that CS was an independent prognostic factor of poor survival (HR, 1.99 for CS1 and 2.59 for CS2, p=.036 and .023, CS0 as a reference), along with extensive stage (p<.001), supportive care only (p<.001) and an elevated lactate dehydrogenase (p=.005). CT-determined CSs, based on the presence of sarcopenia and/or adipopenia, could be used to predict prognosis in male SCLC.