Abstract

The purpose of this study was to evaluate the association of expression of α5β1-integrin with clinicopathologic features and prognosis in cervical cancer. Levels of α5β1-integrin in normal cervical mucosa and cervical cancer tissue were detected with immunohistochemistry. Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance. α5β1-integrin expression was detected in 84.6% (143/169) cervical cancer samples, significantly different from that in normal cervical mucosa (P < 0.05). Positive expression rates of α5β1-integrin in patients with poor histologic differentiation, lymph node metastasis, and recurrence were elevated. Using Kaplan-Meier analysis, a comparison of survival curves of low versus high expression of α5β1-integrin revealed a highly significant difference in human cervical cancer cases (P < 0.05), suggesting that overexpression of α5β1-integrin is associated with a worse prognosis.The α5β1-integrin promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of cervical cancer. The current study indicated that α5β1-integrin may be an independent prognostic factor for cervical cancer patients.

Highlights

  • Cervical cancer (CC) is the second most common malignant diseases of women in the world

  • Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance. α5β1-integrin expression was detected in 84.6% (143/169) cervical cancer samples, significantly different from that in normal cervical mucosa (P < 0.05)

  • We found a correlation between α5β1integrin overexpression and poor survival, which suggests that α5β1-integrin may be an independent prognostic factor for cervical cancer patients

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Summary

Introduction

Cervical cancer (CC) is the second most common malignant diseases of women in the world. More than 500,000 new cases of cervical cancer were reported each year worldwide, of which approximately 1/3 from China mainland. Cervical cancer is a cause of significant morbidity and cancer-related mortality in China women. With the improvement of modern irradiation techniques and development of novel drugs, cervical cancer remains an unsolved problem of oncology both due to the increased rate of local failures and of the distant metastasis. The death rate for cervical cancer has decreased dramatically since the introduction of cervical cytology as a widespread screening procedure, the survival rate at advanced stages of disease has not improved. Characterization of identifiable molecular markers may play an important role in understanding of molecular pathogenesis and in identifying latently prognostic biomarkers for cervical cancer

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