Abstract
Expression and clinicopathological significance of human growth and transformation‐dependent protein (HGTD‐P) in uterine cervical cancer
Highlights
Sir: Cervical cancer is the second most common malignancy in women worldwide
A central coordinator of the hypoxic cellular response is hypoxia-inducible factor-1a (HIF-1a), a master transcription factor regulating the expression of numerous downstream targets.[6,7]
We reported the identification of human growth and transformation-dependent protein (HGTD-P) as a new HIF-1a-responsive protein.[8]
Summary
CIN, cervical intraepithelial neoplasia. P = 0.009, analysed by Pearson’s chi-square test. P = 0.042, analysed by Fisher’s exact test. enhancers of target genes increases the expression of molecules which regulate angiogenesis, glucose transport, glycolysis, tissue invasion ⁄ metastasis and cell proliferation.[6] Recently, we reported the identification of human growth and transformation-dependent protein (HGTD-P) as a new HIF-1a-responsive protein.[8] Although the majority of genes downstream of HIF-1a participate in survival signalling pathways against Ó 2010 Blackwell Publishing Ltd, Histopathology, 57, 479–497.
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