Abstract

Background: Despite great advances in diagnostic and surgical techniques and perioperative treatments have been made, prognosis of gastric cancer is still hardly definable. At the present the concept of gastric carcinogenesis, while confirming the Correa model, draws attention to growth factors (gastrin, Hepatic growth factor, TGFa, VEGF) that seems to be responsible for excessive proliferation of tumor cells. Moreover Cox 2 – PG2 system plays a role in cell proliferation, apoptosis and angiogenesis and this system is believed to operate in gastric mucosa after HP infection.

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