Abstract
The relationship between urinary collecting system invasion (UCSI) and oncological outcomes in renal cell carcinoma (RCC) patients has attracted extensive attention recent years. However, the reports were inconsistent and remain controversial. Thus, we performed a systematic literature search of PubMed, Embase, Web of Science and The Cochrane Library databases to identify relevant studies up to June 2015 and conducted a standard meta-analysis of survival outcomes. 17 studies containing 9012 RCC patients satisfied the inclusion criteria. Pooled HRs for overall survival (OS) and recurrence-free survival (RFS) were 1.45 (95% CI, 1.26–1.66, P < 0.001) and 2.27 (95% CI, 1.54–3.34, P < 0.001), respectively. Further subgroup analysis suggested that UCSI was significant associated with poor cancer-specific survival (CSS) in stage T1–T2 RCC (HR = 2.05, 95% CI: 1.43–2.96, P < 0.001) but not in stage T3–T4 tumors (HR = 1.08, 95% CI: 0.63–1.85, P = 0.771). Current evidence revealed that UCSI has a significant negative impact on OS and RFS in RCC patients and could be used to predict CSS especially in localized RCC. Thus, RCC patients with UCSI should be paid more attention by clinician and pathologist and require close follow up for their poor prognosis.
Highlights
Et al.[11] suggested that UCSI was disqualified as individual prognostic factor for Renal cell carcinoma (RCC) and did not advocate the inclusion of UCSI into upcoming TNM staging systems
The relationship between UCSI and oncological outcomes in RCC patients has attracted extensive attention and been widely debated, the reports remain controversial and there has yet to be a consensus on whether UCSI should be included in the following AJCC staging system[25,26]
We systemically review the published studies that evaluated the impact of UCSI on RCC survival and conducted a standard meta-analysis to clarify the prognostic value of UCSI in patients with RCC
Summary
Et al.[11] suggested that UCSI was disqualified as individual prognostic factor for RCC and did not advocate the inclusion of UCSI into upcoming TNM staging systems. Understanding the relationship between UCSI and RCC outcomes is very important for the prognostic models establishing. To derive a more precise evaluation of the prognostic significance of UCSI in RCC patients, we systematically review published relevant studies and carried out a meta-analysis by standard techniques
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