Abstract
Objective : Presently, there is no reliable method that allows accurate prediction of the clinical course of an individual superficial bladder tumour. As 10-20% of superficial bladder tumours will become invasive, the discovery of a single or combination of prognostic markers would allow the early establishment of appropriate treatment regimens that could potentially prolong patient life. The aim of this study was to evaluate the potential of both p27 and epidermal growth factor receptor (EGFR), individually and in combination as prognostic markers for bladder cancer. Patients and methods : Immunohistochemistry was used to assess bladder tumours for p27 (54 samples), nuclear EGFR (65 samples) and 49 biopsies for both markers. Results : To assess p27 expression, a cut-off value of 30% was employed. Associations were found between p27 status and grade, stage, disease recurrence and progression ( p =0.0113, 0.0001, 0.0167 and 0.0024, respectively). Patients presenting with p27 positive tumours had longer dis...
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