Abstract
Cyclin B1 is a key mitotic cyclin in the G2-M phase transition of the cell cycle and is overexpressed in various malignant tumors. Numerous studies have reported contradictory evidences of the correlation between cyclin B1 expression and prognosis in human solid tumors. To address this discrepancy, we conducted a meta-analysis with 17 published studies searched from PubMed and Medline. Cyclin B1 overexpression was significantly associated with poor 3-year overall survival (OS) (OR = 2.05, 95% CI = 1.20 to 3.50, P = 0.009) and 5-year OS (OR = 2.11, 95% CI = 1.33 to 3.36, P = 0.002) of solid tumors. Subgroup analysis revealed that elevated cyclin B1 expression was associated with worse prognosis of lung cancer and esophageal cancer but better prognosis of colorectal cancer. In summary, overexpression of cyclin B1 is correlated with poor survival in most solid tumors, which suggests that the expression status of cyclin B1 is a significant prognostic parameter in solid tumors.
Highlights
It is universally acknowledged that dysregulation of the cell cycle is closely correlated with proliferation of cancer cells, and is a hallmark of human carcinomas [1]
Overexpression of cyclin B1 was demonstrated to correlate with adverse survival outcome, while some others showed cyclin B1 was a potential biomarker for favorable prognosis
We thoroughly assessed survival data of 2492 solid tumor patients in 17 different studies and proved that the expression of cyclin B1 was a prognostic marker of unfavorable clinical outcome, with consistent results of overall survival (OS) at 3- and 5-years
Summary
It is universally acknowledged that dysregulation of the cell cycle is closely correlated with proliferation of cancer cells, and is a hallmark of human carcinomas [1]. Progression of cell cycle is mediated by a series of cyclindependent kinases (cdks) and cyclins. Cyclins play vital roles at various phases of the cell cycle by activating specific cdks. Among various cyclin/cdk complexes regulating the cell cycle, cyclin B1/Cdc is a widely studied complex, which controls G2-M phase checkpoint surveillance, and is essential for initiation of mitosis [2]. Cyclin B1, encoded by the CCNB1 gene [3], has been demonstrated to play a pivotal role in tumorigenesis and tumor development. Deregulation of cyclin B1 can result in unrestricted cell-cycle progression and malignant transformation [4–7]. A plenty of studies revealed that cyclin B1 is implicated in the differentiation, growth, apoptosis, metastasis and chemoresistance of cancer cell [14, 17–20]. The prognostic merit of cyclin B1 overexpression in various solid tumors is still disputed
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