Abstract
1076 Background: Expression of androgen receptor (AR) was reported to be associated with estrogen receptor (ER) expression and predict better disease-free survival (DFS) and overall survival (OS) in early breast cancer. The prognostic role of AR expression in triple-negative breast cancer (TNBC) is unclear. We performed a meta-analysis of published clinical studies to date. The Cancer Genome Atlas (TCGA) data was used to evaluate the association of AR expression with survival outcomes in TNBC. Methods: PubMed was searched for eligible clinical studies that investigated the association of AR expression with clinical outcomes (DFS and/or OS) of TNBC. Pooled hazards ratios (HRs) for survival outcomes with 95% confidence interval (CI) were calculated using Comprehensive MetaAnalysis (v2). AR mRNA expression, clinical information and survival data of breast cancer patients were extracted from the TCGA Data Portal. OS of TNBC patients with different levels of AR expression was compared using Cox-proportional ha...
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