Abstract
To evaluate the prognostic role of androgen receptor (AR) expression in patients with TNBC. The effect of the AR expression level in tumor tissue on overall survival depending on clinical, histological and immunohistochemical characteristics of the tumor was evaluated in 116patients with metastatic TNBC. The independent prognostic value of AR expression in patients with TNBC of different stages was shown. The median overall survival was higher in patients with AR-positive tumors compared with AR-negative tumors (57months vs 27months, p < 0.0001). Five-year survival since diagnosis in the group with AR-positive TNBC was 47.6 ± 8.3% vs 20.0 ± 5.3% in the group with AR-negative TNBC (p < 0.05). The results of our study indicate a favorable impact of AR expression on the overall survival of TNBC patients.
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