Abstract
Bckground and Aim: Acute-on-chronic liver failure (ACLF) defines an abrupt and life-threatening worsening of clinical conditions in patients with cirrhosis or chronic liver disease. APASL defines ACLF as an acute hepatic insult manifesting as jaundice (total bilirubin >5 mg/dl) and coagulopathy (INR of >1.5) complicated within 4 weeks by clinical ascites, encephalopathy or both in patients with compensated cirrhosis (diagnosed or undiagnosed) or non-cirrhotic chronic liver disease. Serum ferritin, an acute phase reactant is a known marker of hepatic necro-inflammation and has been studied to predict 1-year mortality in decompensated cirrhotics.
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