Abstract
To analyze the relationship between the transcriptional expression of lactate dehydrogenase A (LDHA) and the disease control in patients with a head and squamous cell carcinoma (HNSCC). We determined the transcriptional expression of LDHA in 110 HNSCC patients treated with surgery. Five-year disease-free survival for patients with a high transcriptional expression of LDHA (n= 51) was 39.2% (95% confidence interval [CI]: 25.3%-53.1%), and for patients with a low expression (n= 59), it was 63.6% (95% CI: 51.1%-76.1%) (p= 0.004). According to the results of a multivariate analysis, patients with a high transcriptional expression of LDHA had a 3.4-fold increased risk of tumor recurrence. Patients with a high transcriptional expression of LDHA tended to show a higher intensity of immunohistochemical expression of LDHA at the tumor cells (p= 0.086). In HNSCC patients treated with surgery, a high transcriptional expression of LDHA was associated with a significant decrease in disease-free survival.
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