Abstract
Objective To investigate the expression and clinical significance of lactate dehydrogenase A (LDHA) in breast cancer. Methods Tissue samples of 76 breast cancers and corresponding paired adjacent normal tissues were collected and made into tissue microarrays (TMAs). Immunohistochemistry (IHC) analysis was performed to detect the expression of LDHA and further analyzed the correlation of LDHA expression and clinicopathological variables and prognosis of breast cancers. Results LDHA was frequently upregulated in breast cancer tissues compared to the normal breast tissues (P<0.05). High LDHA expression was associated with distant metastasis (P<0.05) and worse patient prognosis (P<0.05). Conclusions LDHA is closely related to the occurrence and clinical progress of breast cancers. LDHA might be a potential novel molecular marker for diagnosis, prognosis and therapy in breast cancers. Key words: Lactate dehydrogenases/ME; Breast neoplasms/ME
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