Prognosis of Breast Cancer Patients Underwent Surgery in a Developing Country

Bangaly Traore,Mamoudou Condé,Telly Sy,Ahmadou Deme,Mamadou Moustapha Dieng,Abdoulaye Toure,Namory Keita

doi:10.4236/jct.2015.69088

Abstract

Background: We aim to review different factors associated with the relapse and the mortality in breast cancer patients in restricted-resource settings over a five-year period. Method: A retrospective cohort study including 133 women underwent breast cancer surgery was performed at the Surgical Oncology Unit of the Conakry University Hospital in Guinea. Socio-demographical characteristics, clinical information, treatment and data on relapse and survival were retrieved from medical files. Predictor factors of relapse were analyzed by using univariate and multivariate logistic regression. Factors associated with mortality were analyzed by Kaplan Meier survival and Cox models. Results: Breast cancer surgery was conservative in 13 cases (9.8%) and radical in 120 cases (90.2%). Five-year relapse was 33.8% ± 8.0% and the predictor factors of this relapse were age and stage III (p = 0.005). The overall 5-year mortality was 42.1% and the risk factors independently associated with death were body mass index (p = 0.01), origin of patients (p = 0.02), radiotherapy (p = 0.01) and cancer relapse (p = 0.001). Conclusion: The proportions of relapse and death were higher in breast cancer patients. The age and the stage of cancer at the time of surgery were the predictor factors of relapse. Body mass index, origin of patients, radiotherapy and cancer relapse were associated with death.

Highlights

Cancer is recognized as a critical public health problem in Africa
Breast cancer is a major cause of morbidity and cancer related mortality among African women
We analyzed the factors associated with the occurrence of relapse and mortality of breast cancer patients who underwent surgery in our surgical oncology unit in Conakry, Guinea

Summary

Introduction

Breast cancer is a major cause of morbidity and can reach high mortality among women. The incidence of this cancer has been progressively increasing worldwide. In Sub-Saharan Africa, the incidence of breast cancer ranged from 15 to 53 per 100,000 women, which are lower than those in industrialized countries [2]. We aim to review different factors associated with the relapse and the mortality in breast cancer patients in restricted-resource settings over a five-year period. The overall 5-year mortality was 42.1% and the risk factors independently associated with death were body mass index (p = 0.01), origin of patients (p = 0.02), radiotherapy (p = 0.01) and cancer relapse (p = 0.001). Origin of patients, radiotherapy and cancer relapse were associated with death

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