Abstract
The modulating effects of progesterone on endometrium structure and function are the basis for successful outcome in reproductive treatments. Considering this, progesterone has a big role in treatment of infertility and supporting the ongoing pregnancy. In this review article we have attempted to review different forms of progesterone, their metabolism in the body and the role played by exogenous as well as endogenous progesterone in assisted reproductive technologies (ART). Elevated serum progesterone levels at the end of the follicular phase in controlled ovarian stimulation (COS) leads to a poorer ongoing pregnancy rate in IVF cycles due to reduced endometrial receptivity.
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