Abstract
Lipid nanoparticles (LNPs) have emerged as a prominent delivery system for nucleic acid drugs, attracting significant attention especially through the successful development of several commercial products. As a key component in LNPs, cationic lipids along serve as key technical barrier to block competitors by building up complex patent thicket. However, there have been few studies as yet that have comprehensively analyzed the patented compounds in LNP formulations, despite a large number of technical reviews and original articles. In the context, this study focuses on analyzing the macroscopic landscapes and microscopic molecular characteristics of LNP patents, aiming to provide a valuable reference for researchers and developers in making informed technological and commercial decisions. By mining 2,994 patents, 265 formulas, 7,674 compounds and 28,789 fragments, this work sketched the empirical golden ratio of lipid materials in LNP formulation, disclosed the advanced technology in the formulation, characterized high-frequency fragments of heads, linkers and tails in both novel cationic lipids as well as targeting lipids, and established a virtual focus library of LNP materials.
Published Version
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