Profiles of histopathological lesions of urinary bladder: A five years study

Ep Shrestha,K Karmacharya

doi:10.3126/jpn.v6i12.16287

Ep Shrestha, K Karmacharya

Open Access

https://doi.org/10.3126/jpn.v6i12.16287

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Abstract

Background: Neoplastic and non-neoplastic urinary bladder lesions are the main reasons for morbidity and mortality throughout the world. Amongst these, urothelial carcinoma is a common primary tumor of urinary bladder (90%). The objective of this study is to determine the profile of various urothelial lesions received in Army Hospital within 5 years of period.Materials and methods: Five years retrospective study of cystoscopic biopsies and radical cystectomy specimens were carried out in Department of Pathology, Army hospital.Results: Out of 53 cystoscopic biopsies and radical cystectomy specimens, 42 were neoplastic and 11 were non neoplastic lesions. Thirty six urothelial carcinomas were observed out of which 20 were high grade urothelial carcinoma and 16 were low grade. Out of 20 high grade urothelial carcinoma, 17 had muscle invasion and 3 had invasion upto lamina propria. Of 16 low grade urothelial carcinoma, 12 were noninvasive, 2 had invasion upto lamina propria and 2 had muscle invasion. Papilloma was the commonest benign lesions found (7.1%) followed by papillary urothelial neoplasms of low malignant potential (PUNLMP) (2.4%) and hemangioma (2.4%).Conclusion: This article have highlighted upon the importance of histopathological study in evaluating urinary bladder lesions. Also, it has helped in determining that neoplastic lesions were more common than non-neoplastic lesions as seen in our study. A great majority of neoplastic lesions were of urothelial origin. Cystoscopic studies and biopsies help in early detection of bladder neoplasms and they form the mainstay of the diagnosis and follow up.

Highlights

IntroductionNeoplastic and non-neoplastic urinary bladder lesions are collectively responsible for significant morbidity and Correspondence: MATERIALS AND METHODS
Neoplastic and non-neoplastic urinary bladder lesions are collectively responsible for significant morbidity and Correspondence: MATERIALS AND METHODSThis is a retrospective analysis of biopsies taken from urinary bladder were performed in Army hospital
2 cases were of cystitis glandularis, which showed slitlike and cystic spaces, lined by cuboidal and columnar epithelium and a rim of urothelium, which were present in lamina propria which co-relates well with the study shown by Semins et al.[9]

Summary

Introduction

Neoplastic and non-neoplastic urinary bladder lesions are collectively responsible for significant morbidity and Correspondence: MATERIALS AND METHODS. This is a retrospective analysis of biopsies taken from urinary bladder were performed in Army hospital. Prior to study permission was obtained from institutional review committee. A total 53 biopsies were reviewed within 5 years of period. All cystoscopic biopsies and radical cystectomy specimens were included in the study. Neoplastic and non-neoplastic urinary bladder lesions are the main reasons for morbidity and mortality throughout the world. Urothelial carcinoma is a common primary tumor of urinary bladder (90%). The objective of this study is to determine the profile of various urothelial lesions received in Army Hospital within 5 years of period

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Conclusion