ProFertil study protocol for the investigation of gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy aiming at fertility protection of young women and teenagers with cancer in Sweden—a phase III randomised double-blinded placebo-controlled study

Jonas Bergh,Per Ljungman,Per Frisk,Helena Mörse,Lovisa Vennström,Johan Malmros,Christina Linder Stragliotto,Antonis Valachis,Barbro Linderholm,Erika Isaksson Friman,Hanna Pauline Nilsson,Sandra Eloranta,Sara Harrysson,Theodoros Foukakis,Kenny A Rodriguez-Wallberg,Anne Andersson

doi:10.1136/bmjopen-2023-078023

ProFertil study protocol for the investigation of gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy aiming at fertility protection of young women and teenagers with cancer in Sweden—a phase III randomised double-blinded placebo-controlled study

Jonas Bergh, Per Ljungman + Show 14 more

https://doi.org/10.1136/bmjopen-2023-078023

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Journal: BMJ Open	Publication Date: Dec 1, 2023
Citations: 2	License type: CC BY 4.0

Affiliation: Karolinska Institutet, Karolinska University Hospital, Uppsala University Hospital, Skåne University Hospital, Sahlgrenska University Hospital, Saint Göran Hospital, University Hospital of Umeå

#Gonadotropin-releasing Hormone Agonists #Principles Of Good Clinical Practice + Show 8 more

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Abstract

BackgroundGonadotropin-releasing hormone agonists (GnRHa) cotreatment used to transiently suppress ovarian function during chemotherapy to prevent ovarian damage and preserve female fertility is used globally but efficacy is debated. Most clinical...

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