Proefschriften 25 jaar na dato 48. Effect van speeksel op de kolonisatie van mondbacteriën

Abstract

In the research that formed the basis of the dissertation 'Intervention of saliva in the colonization process of oral bacteria' from 1992, the aggregation or clustering of oral bacteria by saliva was investigated. This prevents bacterial colonisation in the mouth. Major individual differences in aggregation activity of different saliva samples were found to exist, partly determined by the blood group of the saliva donor. As well as being found in red blood cells, AB0 blood group antigens also appear on salivary glycoproteins. This does, however, not hold true for all individuals: this is only the case for so-called secretors. Non-secretors aggregated fewer bacteria than secretors. Later research showed that this was associated with a higher risk of caries. Subsequent research revealed that the complement system, a defence system in blood, was activated by saliva of secretors, but not of non-secretors. This shows that the oral defence systems are influenced by blood group and secretor status, but in a different way than we originally thought.