Abstract
Objective: ABO blood group and secretor status is valuable in relation to some diseases in clinical and forensic medicine. Across the globe there are geographic and racial differences in the frequency of secretors and non-secretors. Aim of this study was to evaluate the status of ABH blood group secretors and non-secretors in Karachi (Pakistan). Methods: Blood and saliva samples were randomly collected from one hundred and one (n=101) healthy adult students (76 male, 25 female) ranging in age from 15 to 40 years. Their ABO and Rhesus blood groups were determined by conventional methods, and their secretor status was studied by hemagglutination inhibition method of saliva. Results: Results showed that 64.4% of the study population were ABH blood group secretors while 35.6% were non-secretors. Frequencies of the secretor status among various ABO blood groups were 71.4% in group A, 79.5% in group B, 45.5% in group AB, and 61.5% in group O. Conclusion: Frequency of ABH secretor is high (64.4%). Blood group B has the highest secretor (79.5%) frequency while Blood group AB has the lowest (45.5%).
Highlights
An Austrian Scientist Karl Landsteiner discovered the ABH blood group system in 1901.1 In 1926 it was found that A and B antigens were present1
Their ABO and Rhesus blood groups were determined by conventional methods, and their secretor status was studied by hemagglutination inhibition method of saliva
Results showed that 64.4% of the study population were ABH blood group secretors while 35.6% were non-secretors
Summary
ABH secretors secrete ABH substances according to their blood groups. Non-secretors have high incidence of diseases of mouth, esophageal cancer, epithelial dysplasia as compared to secretors.[9] ABH soluble substances in intestinal secretions increase the brush border hydrolase enzyme activity that has significant effects on bacteria and lectin adherence to the microvilli of the intestine. It has been found that some bacteria in the GI tract produce ABH degrading enzymes and use ABH substances for constant food supply. Bacteria capable of degrading blood group “B” antigen produce enzymes that allow them to detach the terminal alpha-D-galactose and use these sugars for food. Frequency of secretors and non-secretors of ABO blood group system has not been determined yet in Pakistan. Aim of this study was to evaluate the prevalence of ABH blood group secretors and nonsecretors in Karachi (Pakistan)
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call