Abstract
In this study, the optimum synthetic process of the Pyracantha polysaccharide-iron (PPI) complex was studied via response surface methodology (RSM). Its antioxidant and anti-cancer activities were also investigated. It was demonstrated that the optimal conditions for the synthetic process of the complex were as follows: a pH of 8.9, a reaction temperature of 70 °C and a trisodium citrate:polysaccharide ratio of 1:2. PPI were analysis by UV, FTIR, SEM, CD, XRD, TGA and NMR. PPI was able to scavenge the metal ion, ABTS and free radicals of the superoxide anion, demonstrating its potential antioxidant activity. PPI was found to display cytotoxicity to Skov3 cells, as shown by its ability to induce apoptosis and alter gene expression in Skov3 cells. These findings show than PPI may represent a novel antioxidant and chemotherapeutic drug.
Highlights
Pyracantha polysaccharide-iron (PPI) possessed another peak at 672.47 cm−1. This suggests that the core of the polysaccharide iron complex was a β-FeOOH nucleus, which is consistent with the report of Marshall [19]
Molecules 2021, 26, x this suggests that the core of the polysaccharide iron complex was a β-FeOOH nucleus, which is consistent with the report of Marshall [19]
The PPI produced was a reddish-brown powder with an iron content of PPIC that reached 30.76%, which suggests that the model was satisfactory and accurate
Summary
Polysaccharide iron complexes are usually complexes of ferric ions [5,6] These compounds have a relatively high iron concentration and can be soluble and non-toxic at physiological pH values, making them an efficacious iron supplement in the body [7]. Many studies have shown that the polysaccharide iron complex possesses high stability, water solubility and a good absorption rate [8,9,10]. It has a safer adverse event profile compared to ferrous sulphate.
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