Abstract
Prostaglandin (PG) I 2 (mesured as 6-keto-PGF 1α) was the major PG synthesized by aortic homogenates from normotensive and hypertensive male rats, with lesser quantities of PGF 2α and PGE 2. Homogenates of vena cave from the same rats synthesized PGI 2 and PGE 2 in similar quantities. PGF 2α synthesis by aortic homogenates was significantly higher in hypertensive than in normotensive male rats. A similar trend was seen in PGF 2α synthesis by homogenates of the vena cava. Separation of the aorta of normotensive and hypertensive, male rats showed that PGI 2 was the major PG synthesized by endothelial cells and smooth muscle, and that PGF 2α was the major PG synthesized by adventia. PGI 2 synthesis by smooth muscle and PGE 2 synthesis by endothelial cells were lower, and PGF 2α synthesis by endothelial cells and smooth muscle were higher in hypertensive than in normotensive, male rats. PGI 2 was the major PG released from the aorta of normotensive and hypertensive male rats, together with lesser quantities of PGE 2 and PGF 2α. Aortic PGF 2α output, but not PGI 2 and PGE 2 outputs, was significantly higher in hypertensive compared to normotensive, male rats.
Published Version
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