Abstract
Prodigiosin is a promising drug owing to its reported characteristics of having antifungal, immunosuppressive and anti-proliferative activity. Prodigiosin was first characterized from Serratia marcescens. Investigations were made in the present study to screen new strains of Serratia that effectively produce prodigiosin. A new strain designated as S. marcescens NY1 was isolated. The parameters viz., temperature, pH, sugar substrate and oil substrate were optimized to increase the production of prodigiosin. It was observed that maximum amount of prodigiosin was produced at temperature 30°C and pH 7.0. Among the different sugar substrates tested maltose when amended in the medium yielded 425±40 mg/L of prodigiosin. Oil substrates play a vital role in prodigiosin production. Among the various oil substrates used the production of prodigiosin was maximum (535±45 mg/L) when the medium was amended with peanut oil. Keywords: Prodigiosin, Serratia marcescens, biopigments
Highlights
Estimation of Prodigiosin (Slater et al, 2003)Natural products represent one of the critical sourcesThe organisms were harvested by centrifuging at of chemical diversity and potential medicinal use. 10,000 rpm for 10 minutes
The supernatant was a red pigment produced by many strains of the bacterium transferred to a fresh vial and observed under UV-visible like Serratia marcescens and some other unrelated spectrophotometer at 534 nm
The present study focuses on screening new strains pigment production the isolate was cultivated in the of Serratia that produces prodigiosin and to optimize the presence of different sugars viz., maltose, glucose, culture medium for effective pigment production
Summary
The organisms were harvested by centrifuging at of chemical diversity and potential medicinal use. 10,000 rpm for 10 minutes. The prodigiosin reported that prodigiosin revealed a broad range of production was estimated after incubation. The inhibitory activities against many bacterial, fungal and temperature at which maximum production of prodigiosin protozoan species while he tested these organism was observed was chosen and maintained in the against the naturally produced anti microbial products. The initial pH at which maximum production of prodigiosin was observed was chosen and maintained in the genetically transform the enzymes responsible for following studies. Prodigiosin production from Serratia marcescens to Effect of different sugar substrate on pigment production. The present study focuses on screening new strains pigment production the isolate was cultivated in the of Serratia that produces prodigiosin and to optimize the presence of different sugars viz., maltose, glucose, culture medium for effective pigment production. Prodigiosin production was maximum at pH 7.0 (Fig. 2)
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