Production of pneumonic lesions by intrabronchial insufflation of unorganized substances

Abstract

Earlier communications from this department have shown that intrabronchial insufflations of virulent pneumococci in dogs produce lobar pneumonia similar in every respect to the lesions of lobar pneumonia as observed in human beings. In later experiments, Wollstein and Meltzer demonstrated that, at least macroscopically, typical pneumonic lesions can be produced also by avirulent pneumococci and by the saprophytic bacillus megatherium. Microscopically it was established that the lesions produced by the virulent pneumococci contained a great amount of fibrin, while the lesions produced by the last-named organisms (avirulent pneumococci and bacillus megatherium) contained only very little fibrin.In the present series of experiments various unorganized substances were insufflated into the bronchi of dogs which were killed after twenty-four or forty-eight hours. The substances were: aleuronat suspension in starch solution (autoclaved), starch solution, egg yolk, lecithin, egg white and cholesterin. The results...